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Thursday, September 25, 2008

Medical doctors have not been getting the full picture about newly FDA-approved drugs, concludes a research team from the University of California, San Francisco. This is because not all the studies required for FDA approval get published. New drug studies that do see publication tend to be ones where the medicine appears to perform well while poor and middling results are less likely to appear in medical journals. The result appears to be that doctors who read the available literature may get an inflated impression of new medications and may prescribe expensive new drugs in place of older medicines that perform as well or better. As Jordan Lite of Scientific American wonders, are drug companies cherry-picking the studies they publish to make their drugs look better than they actually are?

The University of California team reviewed trials that had supported new drugs approved from 1998 to 2000 and examined 909 trials of 90 medications. The search was conducted upon PubMed and other search tools that a typical medical doctor or patient could access. They concluded that less than half of the studies had been published five years after drug approval and a publication bias existed.

Erick Turner, who coauthored a similar study earlier this year, expressed concerns to Scientific American that the problem was not merely the raw percentage of studies published, but that a disproportionate share of the research that appeared in journals are examples where new medications appear to perform well:

When trials are selectively published … it will skew the efficacy of the drug and make it look like it works better than it does. It’s going to create a lot more enthusiasm among consumers of that information or in the words of Alan Greenspan, ‘irrational exuberance.’

Ken Johnson, senior vice president of the Pharmaceutical Research and Manufacturers of America (PhRMA), defended the pharmaceutical industry by saying FDA review of new drug applications is more important than publishing the results of medication trials in medical journals. Approved medications come with labels that give patients and doctors enough information, assures Mr. Johnson.

Yet concerns about full and appropriate disclosure have been serious enough that a new law was enacted last year. FDA Amendments Act of 2007 (FDAAA) requires that all trials which support FDA-approved drugs be registered at the National Institutes of Health website. The requirement goes into effect this coming Saturday. Congress enacted the legislation in response to hearings that determined pharmaceutical companies were less likely to publish studies that indicated significant side effects. One shortcoming in the legislation, according to UCSF associate professor Ida Sim, is that the FDA is still not required to specify which trials it weighs when considering applications for drug approvals. Yet she praises the new law as a major improvement. It’s critically important that we know trials exist and that we get the summary results, positive and negative, into the public domain—that’s a huge step and more than any [other] country is doing now.

Friday, February 2, 2018

On Wednesday, English football club Arsenal FC announced signing Gabonese striker Pierre-Emerick Aubameyang from German club Borussia Dortmund (BVB) on “a long-term contract” which runs until 2021. The deal is worth about £56 million, making Aubameyang the costliest player in the history of the club.

The 28-year-old striker joined Borussia in 2013 from French club Saint-Etienne, and since then, scored 141 goals in 213 matches for BVB. In German Bundesliga, he scored 98 goals, scoring one goal in 116 minutes on average. During his tenure at the Signal Iduna Park, the Gabonese captain won the 2017 DFB-Pokal (German Cup).

Aubameyang scored 31 goals in Bundesliga last season. Aubameyang was named 2016 Bundesliga player of the year. A year earlier, in 2015, he won African Footballer of the Year award. He has 56 international caps with Gabon and has netted 23 goals.

Via their official website, Arsenal announced Aubameyang is to wear jersey number 14, previously worn by Theo Walcott until last month when he moved to Everton FC. The Gabonese, who has already scored 21 goals in 24 games this season, reunites with Armenian midfielder Henrick Mkhitaryan. They were teammates at Dortmund until 2016, when Mkhitaryan moved to Manchester United. Mkhitaryan’s transfer to the London club came in exchange of Chilean forward Alexis Sanchez moving from Arsenal to their rivals Manchester in a swap deal.

Dortmund had signed Belgian footballer Michy Batshuayi from Chelsea on loan before Aubameyang’s deal was agreed upon. With Aubameyang’s arrival, French forward Olivier Giroud moved to Arsenal’s cross-town rivals Chelsea. In summer, Arsenal had signed Alexandre Lacazette for a then-club record fee of around £46.5 million.

Sunday, July 31, 2016

The Italian Interior Ministry has collaborated with the International Organisation for Migration (IOM) to produce an on- and offline media campaign aimed at discouraging refugees from entering Europe. The campaign, titled “Aware Migrants”, was launched Thursday, exposing high levels of violence and danger in transit, and discouraging migrants from attempting passage through illegal trafficking.

The €1.5million campaign features videos on social media to target the 16–35 age demographic, believed to be most likely to attempt the move. The videos are to include testimonials from more than 150 refugees, citing rape, child abuse, and exposure as potential threats. Each video concludes with the phrase “Be aware, brother” or “Be aware, sister”. This slogan is also thematic in Malian musician’s Rokia Traoré’s official campaign song: “Be aware brother, be aware sister”.

Italy’s Interior Minister, Angelino Alfano, said they will still welcome refugees fleeing war, but that others may be declined. Recent large numbers of arrivals and migrant deaths has been cited as the reason behind the campaign, with the Interior Ministry recording over 70,000 refugees arriving in Italy in the first half of 2016. Federico Soda, the Director of the IOM Coordination Office for the Mediterranean, asserts most of those migrants did not expect the level of danger involved in transit.

Migrants are invited to share their own experiences in response to the videos posted on Facebook, Twitter, and YouTube, in order to spread the warning to other potential migrants.

Thursday, March 18, 2021

On Monday, Kim Yo Jong, vice department director of the Central Committee of the Workers’ Party of Korea and sister of the North Korean leader Kim Jong Un, warned the United States and South Korea as a reaction to the joint military drills conducted by the US and South Korea.

In a statement released by the Rodong Sinmun, Kim Yo Jong said: “The peaceful spring days of three years ago are unlikely to return”. Arirang News asserted the “peaceful spring” refers to the inter-Korean meetings held in April 2018.

In her statement, Kim described ‘the south Korean authorities’ as “all born with stupidity” and “become the dumb and deaf bereft of judgment”. In response to the drills — which the North Korean government reportedly perceived as a threat — Kim expressed the possibility of closing various inter-Korean organizations like the Committee for the Peaceful Reunification of the Country and the Kumgangsan International Tourism Bureau. “We also examine the issue of dissolving the Kumgangsan International Tourism Bureau and other organizations concerned as any cooperation and exchange with the south Korean authorities antagonizing us are no longer necessary”, Kim said.

Towards the end of the statement, Kim said, “If it [the United States] wants to sleep in peace for coming four years, it had better refrain from causing a stink at its first step.”

Speaking to Arirang News, Yang Moo-Jin, the vice president for public affairs at the University of North Korean Studies, said the message indicates “the regime is willing to talk […] as long as the South [Korean authorities] show some sincerity by not raising tensions through the joint drills”. Lim Eul-chul, a professor of North Korean studies at the Kyungnam University, said the North “is reaffirming its long-held stance that there will be no talks unless sanctions against the regime are lifted”. In an interview with Arirang News, Andrei Lankov, the director of the Korea Risk Group, said the message is nothing out of the ordinary, and similar messages have been coming each spring and the contents of this message are not to be overestimated. He qualified the statement as being “business as usual” and “by the North Korean standards it’s pretty tame”.

Monday, November 28, 2005

SpaceX called off the much-delayed inaugural launch of their new Falcon 1 rocket on Saturday from Kwajalein’s Omelek Island launch site. The intent was to launch the U.S. Air Force Academy’s FalconSat 2 satellite, which will monitor plasma interactions with the Earth’s upper atmosphere and magnetosphere.

The launch was delayed, then finally cancelled after an oxygen boil-off vent had accidentally been left open. The oxygen was unable to cool the helium pressurant, which then proceeded to evaporate faster than it could be replenished. A main computer issue, probably serious enough to cause a scrub on its own, was also discovered.

This long-anticipated flight was originally expected to be launched in January 2005, however a series of setbacks forced a series of delays, with the flight most recently scheduled to be in early 2006. It was intended to be launched from the Kwajalein atoll in the middle of the Pacific Ocean.

The maiden voyage was originally intended to launch from Vandenberg Air Force Base in California with a Naval Research Laboratory satellite and a Space Services Incorporated space burial payload.

Thursday, September 16, 2010

A man shot a faculty physician as well as his own mother before killing himself at Johns Hopkins Hospital in Baltimore, Maryland. The shooting occurred on the eighth floor of the Nelson Building, the hospital’s main building. Baltimore police found the suspected shooter, who had been barricaded inside his mother’s hospital room for several hours before killing himself and his mother.

At around 11:15 a.m. EDT (1515 UTC), an unnamed doctor was shot in the chest at a patient area of the Nelson Building’s thoracic center. All major hospital facilities were placed under a lockdown, and some medical personnel were evacuated from the Nelson Building. The doctor was sent to surgery at the hospital, and police spokesperson Anthony Guglielmi said that the doctor will likely survive the incident. He was not aware of any connections between the suspect and the doctor, who was in critical condition.

A nurse at the hospital told The Baltimore Sun that the shooter was dissatisfied with how his mother had been treated and even said that he was going to jump out of a window. The nurse said that, upon hearing gunshots, she ran.

Earlier, Baltimore area police said that they were “in the process of a tactical operation” to capture the gunman, who was holed up on the eighth floor. A spokesperson for the Federal Bureau of Investigation (FBI) said that it had been assisting local police in the incident. A Johns Hopkins spokesperson had previously said that authorities had taken the shooter into custody, but police said that the report was incorrect.

The suspect, who had not taken any hostages, was described as a black man in his thirties. After a standoff lasting for three hours, law enforcement officers moved into his mother’s hospital room, and found both him and his mother dead from gunshot wounds to their heads. The suspect was first identified as 50-year-old Warren Davis, and his mother as Jean Davis. Police later said that “Warren Davis” was an alias and that his real name was not known.

Baltimore Police Commissioner Frederick Bealefeld, who said that the department is “treating this case as a murder-suicide,” said that no officers reported hearing the shots that killed the two. Police had previously said that the gunman had been shot and killed by police, but police later said that that report was incorrect.

Monday, December 17, 2007

Some personal details of 3 million British learner drivers who had applied for the ‘theory test’ component of their Driving licence have been lost in Iowa, in the USA.

The data was lost on a hard drive that was owned by Pearson Driving Assessments Ltd, a private contractor to the UK driving standards agency.

Details were given by the UK Transport Secretary, Ruth Kelly, in the House of Commons at 1730 UTC yesterday. It is the first major loss of data in the UK since information on 25 million people was lost by HM Revenue in October.

In her statement to MPs, Ruth Kelly confirmed that no banking information was contained within the lost data, nor were individuals’ dates of birth. She highlighted that security measures had been taken, and that the information that had been stored was not in a format “readily usable or accessible” by standard means.

Political figures in the UK continue to raise concerns about both the specific loss of this information, and the nature of governments ability to safely gather and maintain information. Susan Kramer, representing the Liberal Democrats stated “This constant attempt to gather data, to get more data, to know more about you, to link it more together, all of that it seems to me is what comes into question.”